Popular Stomach Acid-Blocking Drugs May Also Target Gingivitis

WHO admits its target on AIDS drugs may be unrealistic.

Muscarinic Blocking Drugs

Muscarinic blocking drugs are compounds that selectively antagonize the responses to acetylcholine (ACh) and other parasympathomimetics that are mediated by activation of muscarinic receptors. These agents are also referred to as muscarinic antagonists, antimuscarinic drugs, and anticholinergics. The belladonna alkaloids, such as atropine, are the oldest known muscarinic blocking compounds, and...

Could drugs inhibiting the mevalonate pathway also target cancer stem cells?

Understanding the connection between metabolic pathways and cancer is very important for the development of new therapeutic approaches based on regulatory enzymes in pathways associated with tumorigenesis. The mevalonate cascade and its rate-liming enzyme HMG CoA-reductase has recently drawn the attention of cancer researchers because strong evidences arising mostly from epidemiologic studies, ...

Ganglionic Blocking Drugs and Nicotine

Transmission through autonomic ganglia is more complex than neurotransmission at the neuromuscular and postganglionic neuroeffector junctions and is subject to numerous pharmacological and physiological influences. In some ganglionic synapses, especially at parasympathetic ganglia, there is a simple presynaptic to postsynaptic cell relationship; in others, the presynaptic to postsynaptic cell r...

Anaphylaxis to neuromuscular-blocking drugs: all neuromuscular-blocking drugs are not the same.

5 January 2015 I n the current issue of Anesthesiology, Reddy et al.1 report a two-hospital, retrospective, observational, cohort study confirming that anaphylaxis is more common with rocuronium and succinylcholine than with atracurium, a topic that is difficult to assess and was first highlighted in this journal in 2003.2 Although any medication can potentially cause perioperative anaphylaxis,...